Triple-negative breast cancer (TNBC) is an aggressive disease, with poor therapeutic alternatives, whose incidence and mortality seem to be increased by smoking habit. In line with our previous evidence (Di Giacomo et al. Food Chem Toxicol 2018,111:393), we evaluated the antitumor properties of the natural sesquiterpene β-caryophyllene (CRY) in triple negative breast cancer as a possible novel targeted therapeutic strategy. Particularly, its effect on the molecular pathways of STAT3 and IL-8, and the involvement of cannabinoid and β2-adrenergic systems, whose control on cell proliferation has been reported, were studied.
New insights in the antitumor effects of β-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems / Di Sotto, A.; Romaniell, D.; Freddoni, G.; Abete, L.; Cocchiola, R.; Di Giacomo, S.; Altieri, F.; Mazzanti, G.; Eufemi, M.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 29 (supplement 3):(2018). (Intervento presentato al convegno International Congress of Targeted Anticancer Therapies tenutosi a Parigi nel 05/03/2018 - 07/03/2018) [10.1093/annonc/mdy047.042].
New insights in the antitumor effects of β-caryophyllene in breast cancer cells: The role of cannabinoid and adrenergic systems
A. Di Sotto;L. Abete;R. Cocchiola;F. Altieri;G. Mazzanti;M. Eufemi
2018
Abstract
Triple-negative breast cancer (TNBC) is an aggressive disease, with poor therapeutic alternatives, whose incidence and mortality seem to be increased by smoking habit. In line with our previous evidence (Di Giacomo et al. Food Chem Toxicol 2018,111:393), we evaluated the antitumor properties of the natural sesquiterpene β-caryophyllene (CRY) in triple negative breast cancer as a possible novel targeted therapeutic strategy. Particularly, its effect on the molecular pathways of STAT3 and IL-8, and the involvement of cannabinoid and β2-adrenergic systems, whose control on cell proliferation has been reported, were studied.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
